Cresto is a cholesterol level lowering medicine, which contains Rosuvastatin calcium as an active ingredient in its formulations. It is classified as statins and used in blood vessels thinning due to high cholesterol.
Crestor actually helps in suppressing bad cholesterol and triglycerides levels and improves good one levels in human body. By suppressing cholesterol levels it helps in reducing the risk factor heart attacks, stroke and other vascular disorders in cardiac patients. If you want even better results with, you have to take care of some diet patterns and lifestyle changes. AstraZeneca Inc manufactures it, and it is approved by USFDA in 2003.
Crestor is prescribed for suppressing risk levels of cardiac attack and stroke due to high cholesterol levels in blood. So it is indicated in below cardiac disorders:
- High blood cholesterol levels (Hypercholesterolemia).
- Hereditary or genetic high blood cholesterol, fats levels (mixed hyperlipidemia),
- Patients with progression of atherosclerosis,
- Homozygous and Heterozygous familial hypercholesterolemia (HeFH),
- Prevention of Myocardial Infarction,
- Prevention of Stroke, and
- Arterial revascularization procedures
Dose, administration and Dosage forms
It is available in tablet formulation in different strengths like 5mg, 10mg, 20mg and 40mg. You can take it with or without food. The usual dose rage may vary from 5mg to 40mg 1x/day depending on the severity level of your disease.
The higher dose 40mg daily is used in those patients not reaching LDL-C goal with lower doses. In paediatric patients with HeFH, the common dose 5mg to 20 mg daily.
Mechanism of action
Going to the mechanism it is reported to be an HMG-Co-A reductase inhibitor. It acts by selectively and competitively inhibiting the HMG-Co-A reductase which is a rate limiting enzyme. This enzyme is responsible for conversion of 3-hydroxy-3-methylglutaryl coenzyme A into mevalonate which is a precursor of cholesterol (LDL and VLDL) production in human body.
Once this enzyme is inhibited in by crestor, the bad cholesterol and triglycerides production decreases in human body resulting in reduced risks of cardiac diseases related to high cholesterol levels.
It also helps in increasing hepatic LDL receptors to enhance uptake and catabolism of LDL. This also inhibits VLDL synthesis resulting in suppressed VLDL and LDL. It also helps in improving good cholesterol (HDL) levels in human body.
Side effects and safety
Now let us look at the side effects. Crestor has a quite good side effects and safety profile. The common side effects associated with its usage includes muscle pain, tenderness, weakness, and fever.
Furthermore, on the side effects of is it may also result in some rare but severe liver problems like yellowing of skin and eyes, dark in colour of urine. It may also cause some gastro issues like severe abdominal pain, persistent nausea and vomiting.
This may also cause some allergic issues like itching resulting in rashes, and facial, tongue or throat swelling, and trouble in breathing. These are some of the main crestor side effects. Most of the side effects are tolerable and easily curable, so you do not have to be worried about its safety profile.
- If you are allergic to crestor, you should not take this medication.
- If you have liver functioning issue, then you must be very careful and continuously keep in touch with your physician so that any unwanted issue can be avoid.
- You must detail your physician about other medicines you are taking before starting it so that any drug interaction can be avoided. The common drugs are contraindicated with crestor are Ciclosporin, Bezafibrate, and Gemfibrozil.
- You must avoid driving and operating machinery, as it may cause dizziness which may lead to some unwanted accident.
- Patients on higher dosing (40mg dose) must be on proper kidney function monitoring.
- If you have a history kidney, liver, and muscle conditions, you must take it with close monitoring.
- You should not take it if you are currently liver, kidney or muscular disease.
- You must avoid taking it if you are pregnant or breastfeeding.